What do neuroscientists really know?

Why is neuroscience suddenly such a hot topic right now? Is it just that the latest brain scan technology allows us to see more detail? The answer is yes, but the implications are far bigger

Why is neuroscience suddenly such a hot topic right now? Is it just that the latest brain scan technology allows us to see more detail? The answer is yes, but the implications are far bigger

So I’m calling it: the margin of costs beyond a founder’s living expenses is now officially zero. What next?
Ever wondered what would happen if anyone actually bothered to check out those incessant claims everyone makes that ‘customer service standards are constantly improving’?
Renowned educational critic Steve Peha is unconvinced that any of the current or proposed major educational reform initiatives will change anything. Ever.

Small traditional businesses? They’re already ‘inside’ the startup world, aren’t they? No. They typically know nothing about such things as Lean Startup, Startup Weekend or Y Combinator, and even when they do, they think it has nothing to do with them. Are they right?

Disappointingly, behaviour change through ‘just gamifying your own health tracking’ doesn’t always work very well. Why not? It just might turn out that, for most of us, personal health tracking is not really a single player game.

There’s a growing interest in introducing an entrepreneurial approach to innovation, whether its happening inside or outside the established organisation

At 12 am one night in 2007, a revolutionary engineering idea popped into Michelle Khine’s head. The rest is history (and chemistry, physics, biotech, nanotech, solar: she seems unstoppable)
In places where prosperity has seemingly reigned forever, sometimes all the big employers and retailers can suddenly disappear: welcome to the startup-only economy. We probably need to start looking at places where this already exists
They often seriously hate each other, administration and street folks. But some people out there just don’t care who hates them: they help these seemingly implacable haters help each other, they save lives and they save everyone money

Neuroscience offers the prospect of an incontrovertible record of the intentions behind everything we do, so jury trials may eventually be deemed unnecessary. But no chip implanted? Guilty as charged!

No dead cows, just real, sustainable beef, made with nothing but yummy stem cells and a touch of magic! All yours for a sizzling €250,000 each. And they’ll get cheaper and cheaper with every passing year (can we call that Moo’s law?)

Investors treat ‘startup founders entrepreneurial inexperience’ as an occupational hazard. Accelerators ‘parachute-in’ entrepreneurial experience in the form of ‘startup acceleration mentors’. Isn’t it time to ask some big questions about this?

We’d all be forgiven for imagining that TechCrunch Disrupt and the DEMO Conference were the only regularly held innovation competition events worth talking about, as far as the tech media were concerned. So imagine my surprise…

“There are venture firms here in The Valley that won’t even fund a company unless they employ lean startup methodologies”

At least five of these forthcoming titles major on a healthcare or safety aspect, illustrating just how far this particular management approach has come from its original niche

Government is understandably fed up with being blamed by society when it doesn’t handle things perfectly, so it wants to be seen to be handing at least some of the responsibility for doing things back to society, but…

Nature chuckles at our feeble, stumbling efforts at computation. Its analog computing resources effortlessly deliver dazzling practical intelligence at microscopic scale with zero tolerance for wasted power

The range of startup titles has expanded dramatically this year, and whatever economic surprises may be in store for us in 2012, this particular sector is looking unstoppable.

He asked some industrial designers to come up with something that was “Bob Dylan songs”. His cryptic demands have been described as ‘intentionally unreasonable’. But maybe that’s why they worked

At that speed, you can see things that you shouldn’t be able to see at all, things that the camera isn’t actually pointing at. Wherever light has been, as it bounces around our world, it can tell us a story about its journey, letting us ‘see around corners’

Is prohibiting this pursuit an infringement upon the freedom of the individual? Should we make this something that anyone should be able to do, wherever they are in the world?

Would you invest in founders pitching a project that you didn’t really believe in, for reasons you didn’t tell them about?

Arts authorities caught publicly admitting to experimenting with ditching the ‘waterfall ‘ approach (where committees endlessly prepare vast unread(able) reports before anyone even considers trying anything new) only to discover that they can get strategic projects done quickly and well after all. Gasp!

Carmack systematically trashes proceduralism

They have another mission-critical job that you probably didn’t know about. They are required to make air travel on this planet safer, more efficient and more environmentally friendly for everyone

Biotechnology book publishing is soaring. It’s making the job of keeping track of ‘what are the most interesting titles coming out, and when?’ almost impossible. This is our first attempt

Investment legend Roger McNamee says mobile has already killed search. Smartphone users hardly use search. Is Google no longer the gatekeeper to the web, business, the world? Will Google+ put them back in the money? Does today’s ‘Facebook for business’ launch roll the dice once again?

The name Plumpy’nut may sound quirky, but this ridiculously simple product idea is already keeping countless famine-struck children from starvation and will save millions of lives

Looking for a video covering the latest developments in the interface between flesh, mind and machine, from fully functional transplants to limb replacements offering superhuman capabilities?

How do you draw the line between entertainment and non-entertainment uses? Who drives the innovation? Does industry get its inspiration from cinema and gaming, or is the entertainment business merely exploiting the technological advances made by the manufacturing industry?

Is that a 31 inch Minority Report interface in your pocket?

For a first-time startup, when the real excitement of early innovation is happening, the daunting business of M&A is usually the last thing on anyone’s mind. But research is showing that the later it starts, the higher the risk

Startup founders, while their venture is still revenue-free, are not really self-employed. Unless they’ve also got a day job, they’re technically unemployed. This fact opens up opportunities for some really imaginative startup incentives

The interaction between startups and startup mentors has a fundamental difference from ‘apprenticeship’, something which has major implications for the future of innovation

What’s happening to bioengineering, in the ‘post-life-synthesis-announcement’ era?

Jessica Livingstone offers her own feelings about what Y Combinator wants and I try to read between the lines

The more you think about what she’s saying, the more shockingly unthinkable it seems: can we now really see what an eye sees without us needing its brain in order to see it?
Are so-called ‘clone startups’ (those hoping to be acquired by the mothership after creating a successful, ‘local language lookalike’) too easily dismissed as ‘non-innovators’?

It all begins with an existential crisis: Professor Marinelli tries to Google himself (just before Google exists) and learns of the man who, in 1909, founded the futurism movement, Filippo Marinetti

Justin Romack’s demo has to be slowed down quite a bit for us sighted folks watching the video

A new report by the US Bureau of Labor Statistics is being mistakenly interpreted as showing that startups are creating fewer jobs. This view somehow manages to completely ignore those odd things investors call ‘exits’.

He just said: ‘I hate the term “minimal viable product.” That’s like telling me “we’re shipping without any features because, well, our investors and advisors told us to ship and fix the product later.”
Overall verdict: a bit of a ‘best kept secret’, offering more than enough insight into less-widely covered sectors of the startup investment scene to justify watching out for next year’s event

Jason ‘Mr. Startups’ Calacanis may not do patents, but he has just done an episode of his weekly TV show where he brought in a seasoned patent attorney and a prolific inventor to take us through the latest developments on the US patent scene

Industrial energy waste turns out to be the most surprisingly overlooked opportunity to make outrageous returns on investment. Energy efficiency in industry is a shockingly untapped market. Modernisation at a single large industrial plant can free up an entire power station

The move away from traditional VCs to Angels features strongly in talk about startup investment. So this seemingly contrary view from the very heart of Silicon Valley is intriguing

Computers understand us if we talk to them as if they were stupid. But when humans talk to each other, we talk in complex social riddles that have always left computers utterly confused about our intentions. Until now.

“What do you want to do here?” Get a job. “Sorry, but you’ll need to go straight back home right now, next please. So, what do you want to do here?” Start a business, employ people “Great! please sit over there with the others”

Are astonishing recent successes with word-free math teaching making a mockery of the traditional textbook approach?

Startup mentoring is education. Why can’t existing government-backed student loan schemes be extended to include startup founders attending accredited startup accelerator programmes?

A non-fictional man who would only speak using formal logic, a founding genius of computer science. Like Spock, he was much stranger than any ordinary alien. A student of his tells a disturbing story about a different but highly relevant kind of alienation.

An onstage tournament in which in-house advocates from either side make their case in front of a live audience and we all try to read between the lines

Is it just about speeding up the rate at which startups emerge, or making them grow faster, or just unintentionally hurrying them on to an earlier demise?

A startup only has to take one person out of unemployment to make a net contribution to job growth. Instead of ‘Jobseekers Allowance’ why not ‘Business Model Seekers Allowance’?

And all that was BEFORE she got into the VC business, and not just the old-style VC business: she does mentoring at TechStars, invested early in UStream, and is CEO of Get Satisfaction, a 50,000+ customer startup which uses social media to support customer relationships

Die-hard sceptics still regarding it as little more than a convenient excuse for a lack of interest in or dedication to study may be surprised by this video, which reflects impressive academic achievement in a discipline which simultaneously challenges, derives value from and provides support for the cognitive distinctiveness that dyslexia represents

The Economist calls you a post-materialist: you don’t feel driven by materialist ambitions. You just need enough to maintain your existing lifestyle, rather than improve it. But what does ‘not being your own boss’ mean in this context?

Nobody invents everything they do, innovating all of the time. Most of the time, we are part of the community, resisting newer untried innovations merely by not abandoning older accepted ones. It’s important for innovators to regularly remind themselves about how it feels to be “everyone else”

We’ve known for some time that relevant learning which takes place outside of lessons seriously improves attainment levels. Surprising breakthroughs in motivating learners to do this are being reported in highly challenging educational environments

It’s an engagement and integration problem

Instead of fanning the flames at the bonfire parties regularly held all over Cambridge to celebrate the outstanding achievements of chip designer ARM holdings, perhaps it’s time to splash on just a little cold water

Somehow, something as seemingly mundane as an ‘online errand service’ is helping us discover surprising new ways to support each other

Ten ideas for weaving the lean, low-investment, iterative, failure-tolerant, build-measure-learn attitude toward giving people constructive ways to spend their time into the fabric of every culture

The detail of our individual genetic makeup is already being used to make diagnoses and treatment decisions, albeit in a slow and cumbersome way. The sheer scale of the computational horsepower that doing this in real time will demand promises to bring the hulking mainframe computer back from the grave

The subjects include: nanomechanics, nanoelectronics, nanocomputing, nanoimaging, nanowires and nanofabrication

Twitter? Maybe he just got lucky. Square, the way to pay with your phone? Others may beat him to it. Square, the way to turn the rest of us into merchantpreneurs? Mr Dorsey may yet live to rule our world

We’ve been looking for a green engineering video ever since our last article on the subject. This excellent briefing definitely makes up for the wait

One theme that appears often in many of these volumes? Discovery processes. If the word ‘innovation’ appears anywhere in your job description, you already know that discovering new discovery processes is a double-edged sword

They’ve got until October, then the US Postal service expects to run out of money. This video shows Congress trying to find out “Where have all the letters gone?”
One irony is that Fred Gage is one of the world’s leading figures in neuroscience, a discipline which was largely spurred by Phineas Gage’s miraculous survival. Another relevant irony (noted in the Wikipedia article about Fred) is that Phineas (1823 – 1860) had no children
Ty Danco’s ludicrously improbable but riveting tale definitely belongs in the history books, alongside AirBnB’s legendary ‘survive by literally eating your own marketing material’ yarn
If Artificial Intelligence is going to automate the world’s entire workforce, we’re all going to need to give up any hope of employment and become startup entrepreneurs and innovation investors instead. They couldn’t possibly automate those, could they?

This is about using what The Economist calls artificial artificial intelligence (like Mechanical Turk, which uses people as artificial computers) to enhance (artificially intelligent) machine vision

Startups from Y Combinator, TechStars, Dave McClure’s 500 Startups and Idealab tell us what life feels like, including being rejected by Y Combinator and successfully reapplying!
Even if you don’t know what on earth a Demand-Side Platform (DSP) is, this panel video offers fascinating insights into the latest things that are keeping people in the online display ad world awake at night
Is it just all about ‘making the right noises’, or can they make a real difference?
Intrapreneurship is not for the fainthearted. Inside established organisations, officially-sanctioned bastions of executive dragon slaying can sometimes be found, filled with fearless risk-takers discretely licensed to systematically shred the company rulebook in their tireless search for innovation
Computer Bowl 1990, pitting the East Coast against the West Coast (apologies to any other legends present but not listed above)
The investors need to be wealthy ($1m+) and few (maximum 500) and the business too small to IPO. Facebook tore that last rule apart. What if the other rules are also eventually relaxed?
The practical essence of your personality will soon be surprisingly easy to steal. The coming generation of virtual reality will be able to appropriate so much of what it is to be you, that things could get seriously out of control

Monsters, zombies, heroes or villains: which of these will we become if video games turn out to be shaping the character of future generations?
Today’s occupiers are in many ways no less ethereal that any lingering spirits which might still be roaming the lonely corridors and passing silently through walls
‘Nobody should claim to be doing innovation’ already sounds like a pretty shocking proposition, but it soon becomes clear that conventional ideas are the last thing to expect from the conversation captured in this extraordinary video

Biology has replaced chemistry as the primary science behind drug discovery: how did this transformation begin, who was involved, and how did it get funded?
“Customer service here, we’ve decided to do whatever we can to put right this terrible thing that happened to you when you used AirBnB. For a start, can we have your bank details, so that we can immediately deposit a million dollars”

They’ve already managed to print a kidney, so it’s only a matter of time. The replicators used are very affordable mods of off-the-shelf inkjets, but the cartridges? You guessed it
They look like apps but they’re really stealth development tools which give your customers the ability to build themselves their own app for your service
Please, no more innovation! Just let us come to terms with the last lot of changes! We prefer standardisation to innovation! This is the sector where innovators are really gladiators
No motors, gears or levers. 100% virtual physics and yet 100% real acoustics. It doesn’t make sense, but it works breathtakingly well. The catch? It isn’t cheap. Yet.
What’s it like being interviewed by Paul Graham when you’re applying to Y Combinator? Watch this unmissable video of intense grilling and inspired brainstorming in front of a live audience
New ‘iterative’ startup methodologies, such as Eric Ries’s Lean Startup and Steve Blank’s Customer Development, raise just as many important new questions about investors as they do about startups
VCs are interested in finding large, untapped markets. They use startups to do the market research needed to find them

TechCrunch writers Paul Carr and Sarah Lacy explore taking this to the next stage: he’s just brought out a memoir, The Upgrade, which breaches confidentiality pledges he made to her. Their unguarded video chat exposes intriguing differences between his blogger and book-writer personas. The book’s film rights have just been sold: so who will play Mike Arrington?
It’s a video of Steve Blank’s first talk after finishing his pioneering Lean LaunchPad course at Stanford
Where is customer service innovation really happening right now? Is it mostly in sales, brands, marketing, call centers, e-commerce, retailing, CRM, products, social media, mobile, games, finance? These titles show that it’s taking place over the entire spectrum
An opportunity to watch Steve Chu, US Energy Secretary, running us through a list of technologies which he hopes will help America reassert itself in the rapidly intensifying struggle for competitiveness and maybe even its very survival

The offshoring phenomenon has provided strong support for the claim that simply increasing the number of suitable graduates will produce enough ‘potential for innovation’ to restore growth and jobs. Until now.
A YouTube clip of Led Zeppelin’s Jimmy Page playing a slow soulful country music version of a classical Chopin prelude with jazz-style backing at London’s Royal Albert Hall accompanied by a giant church organ. He was using a guitar internally modified so that you could bend its B string by pulling down against its shoulder strap peg in 1983
They’ve been around longer. $138m revenue, 55 startups and you’ve never even heard of them
No British press coverage for a major innovation story: biotech legend Una Ryan secures funding from both the UK’s Department for International Development and the Bill and Melinda Gates foundation

Before the current mainstream recognition of ‘gamification as a business strategy’, these issues were rarely taken seriously by outsiders. Now that we’re all interested, these videos are an utter revelation, even to many insiders
You’ve been top of the TechMeme leaderboard for quite a while. Here comes Business Insider
Fred Wilson (the VC world’s leading blogger) makes an insightful comparison between first time and serial entrepreneurs. I was thinking through the ‘who do you go to?’ question
Science is ‘going virtual’ in a big way: rapidly escalating computing horsepower is turning lots of real-world research into simulation-based experimentation. Is this helping or hindering the latest open science initiatives?
No, you don’t need to be a brain surgeon to find this fascinating: bio-integrated electronics is full of unimaginably weird but useful things you can do with things like, you know, live brains. It’s all about making electronic things rubbery
If much higher-than-expected numbers of students join the ranks of the long-term unemployed, most student loans are going to remain unpaid indefinitely. Is the risk of student unemployment higher than the risk of failure for a startup accelerator-boosted founder?
Just trying to describe why over two million viewers think this frivolous-looking video is jaw-dropping will inevitably come out sounding like gobbledygook to all but those who already fully appreciate the sensational breakthrough it represents
After my initial TED-talk-inspired enthusiasm, I became seriously disheartened by the seemingly unanswerable criticisms of Khan Academy’s fairly unadventurous ‘talk and chalk’ style tutorial videos as not really representing a genuine step forward in education. But…
If McKinsey’s believe in it, then even if you are unsure, you’d better get the best briefing you can: these videos may raise just as many questions as answers, but they’re a good starting point
What do you do when your own disruptive new ideas bump into The Innovator’s Dilemma in the large organisation that you work in? Geoffrey ‘Crossing The Chasm’ Moore thinks that this is not necessarily ‘game over’ after all
Sharing is useful, right? Motherhood and apple pie, surely? The stampede of sacred cows being ruthlessly sacrificed in this extraordinary video bonfire of academic vanities lends it an intoxicating but perhaps far too beefy aroma for some
Educational miracle worker Sugata Mitra doesn’t take on small challenges. His original breath-taking discoveries overturned everything we knew about early self-teaching. He’s back with enough equally shocking, more recent findings to justify you watching for fifty minutes.
It would have no problem with repetition, but it might find avoiding hesitation difficult and preventing accusations of deviation pretty much impossible
We’re going beyond innovation here. Instead of the latest technology, we’re getting a tantalising glimpse of things that don’t yet exist, but are making exciting progress in the lab and could ultimately represent enormous advances in almost every field of science and technology if they fulfil their promise
Even the dramatic recent reductions in the cost of spectacles and cataract operations are not doing enough to reduce the catastrophic impact that untreated sight conditions have in the third world, but strangely enough, our appetite for HD on our mobile phones will fix this
Should employers turn their business into startup factories? How could we make this happen?
We know we’re creating problems that the next generation will be left to fix, so the least we can do is to give them the skills to fix them, and yet we’re still failing on a grand scale. The good news is that we’re discovering new ways to help them work out how to do this for themselves.
When things go wrong, you could sometimes be forgiven for imagining that big institutions are indifferent to the effects of social media. This video should clear that up, at least for these household names, which seem fully engaged
Steve Blank and Eric Ries each have different definitions of a startup to ours. None of us nail it

Surprisingly, we had the opposite problem to our usual one with this category: this time we were not quite as inundated with contenders
If you loved that awesome video of advertising icon Alex Bogusky and his dad, reserve yourself some time to watch two generations of Stanford stars tell how their vocations unexpectedly converged
Tractors, farm equipment, built at around one eighth the cost. Industrial equipment too. Superior design. Handmade quality. Problem? Investment. Solve it, and Jakubowski becomes a household word. That might just happen anyway.
For some unfathomable reason, we’ve never covered anything on games design luminary Will Wright, and if that wasn’t bad enough, we never even knew that his latest major project wasn’t even a game.
Apart from biology, our physical world is mostly either dumb, rock hard, or both. We use that hard, dumb stuff to make durable things like tools, vehicles and buildings. Biology, although soft, squishy and smart, somehow also manages to grow incredibly hard things, like shells and teeth. Maybe biology can teach us better ways to make hard stuff too
Googlers get taught how to think more creatively about exploring business models. We mere mortals can sit and watch while guru Alex Osterwalder talks us through the ideas in his bestselling book
I had to work my way through an enormous number of clips to put this together, but I still only scratched the surface. I had to do it now, because soon, there are going to be just too many to even attempt this with any sense of purpose.
If you’re thinking: “Aha! at last, a lean startup skeptic! I always suspected all that MVP and pivot stuff was really just snake oil!” then this video is for you. But buckle up, you’re in for a bumpy user experience
This lab is turning the way social science research is conducted on its head, and that’s not just because the whole thing is online
Even if you find the average recycling innovation story boringly predictable, this one, as it gathers momentum with one ludicrously lucky sustainability discovery after another, will have you cheering along with the audience
These titles are at the leading edge of thinking about where design and innovation meet. Not just in predictable design territory, such as consumer products or web and mobile apps, but also in such diverse fields as cultural development, physiological experience analysis and architectural kinetics

No, it’s not Dave McClure’s customary firehose of expletives that make this video Not Safe For Work. It’s you. You’re Not Safe For Work in a startup, as far as he’s concerned

This astonishing video takes environmental innovation to its outer limits: you’ll need to be pretty imaginative to find a way to invest in the ideas it explores
Startups attempt innovation under conditions of extreme uncertainty. Is it possible that we can find new ways to solve the world’s biggest problems using ‘extreme uncertainty’?
Everyone’s telling us that this young woman has used videos in a new, inspiring way, so we went on a hunt for the videos they inspired