She’s busy composing new biological symphonies

What’s happening to bioengineering, in the ‘post-life-synthesis-announcement’ era?

What’s happening to bioengineering, in the ‘post-life-synthesis-announcement’ era?

The more you think about what she’s saying, the more shockingly unthinkable it seems: can we now really see what an eye sees without us needing its brain in order to see it?
Are so-called ‘clone startups’ (those hoping to be acquired by the mothership after creating a successful, ‘local language lookalike’) too easily dismissed as ‘non-innovators’?

Ty Danco’s ludicrously improbable but riveting tale definitely belongs in the history books, alongside AirBnB’s legendary ‘survive by literally eating your own marketing material’ yarn

It all begins with an existential crisis: Professor Marinelli tries to Google himself (just before Google exists) and learns of the man who, in 1909, founded the futurism movement, Filippo Marinetti
If much higher-than-expected numbers of students join the ranks of the long-term unemployed, most student loans are going to remain unpaid indefinitely. Is the risk of student unemployment higher than the risk of failure for a startup accelerator-boosted founder?

Industrial energy waste turns out to be the most surprisingly overlooked opportunity to make outrageous returns on investment. Energy efficiency in industry is a shockingly untapped market. Modernisation at a single large industrial plant can free up an entire power station

The range of startup titles has expanded dramatically this year, and whatever economic surprises may be in store for us in 2012, this particular sector is looking unstoppable.

If McKinsey’s believe in it, then even if you are unsure, you’d better get the best briefing you can: these videos may raise just as many questions as answers, but they’re a good starting point

At that speed, you can see things that you shouldn’t be able to see at all, things that the camera isn’t actually pointing at. Wherever light has been, as it bounces around our world, it can tell us a story about its journey, letting us ‘see around corners’

Computers understand us if we talk to them as if they were stupid. But when humans talk to each other, we talk in complex social riddles that have always left computers utterly confused about our intentions. Until now.

What do you do when your own disruptive new ideas bump into The Innovator’s Dilemma in the large organisation that you work in? Geoffrey ‘Crossing The Chasm’ Moore thinks that this is not necessarily ‘game over’ after all

Are astonishing recent successes with word-free math teaching making a mockery of the traditional textbook approach?

Startup mentoring is education. Why can’t existing government-backed student loan schemes be extended to include startup founders attending accredited startup accelerator programmes?

Is prohibiting this pursuit an infringement upon the freedom of the individual? Should we make this something that anyone should be able to do, wherever they are in the world?

It would have no problem with repetition, but it might find avoiding hesitation difficult and preventing accusations of deviation pretty much impossible

Is it just about speeding up the rate at which startups emerge, or making them grow faster, or just unintentionally hurrying them on to an earlier demise?

And all that was BEFORE she got into the VC business, and not just the old-style VC business: she does mentoring at TechStars, invested early in UStream, and is CEO of Get Satisfaction, a 50,000+ customer startup which uses social media to support customer relationships

“Customer service here, we’ve decided to do whatever we can to put right this terrible thing that happened to you when you used AirBnB. For a start, can we have your bank details, so that we can immediately deposit a million dollars”

Even the dramatic recent reductions in the cost of spectacles and cataract operations are not doing enough to reduce the catastrophic impact that untreated sight conditions have in the third world, but strangely enough, our appetite for HD on our mobile phones will fix this

It’s an engagement and integration problem

Looking for a video covering the latest developments in the interface between flesh, mind and machine, from fully functional transplants to limb replacements offering superhuman capabilities?

Ten ideas for weaving the lean, low-investment, iterative, failure-tolerant, build-measure-learn attitude toward giving people constructive ways to spend their time into the fabric of every culture

Is that a 31 inch Minority Report interface in your pocket?

The detail of our individual genetic makeup is already being used to make diagnoses and treatment decisions, albeit in a slow and cumbersome way. The sheer scale of the computational horsepower that doing this in real time will demand promises to bring the hulking mainframe computer back from the grave

The subjects include: nanomechanics, nanoelectronics, nanocomputing, nanoimaging, nanowires and nanofabrication

We know we’re creating problems that the next generation will be left to fix, so the least we can do is to give them the skills to fix them, and yet we’re still failing on a grand scale. The good news is that we’re discovering new ways to help them work out how to do this for themselves.

Twitter? Maybe he just got lucky. Square, the way to pay with your phone? Others may beat him to it. Square, the way to turn the rest of us into merchantpreneurs? Mr Dorsey may yet live to rule our world

They’ve got until October, then the US Postal service expects to run out of money. This video shows Congress trying to find out “Where have all the letters gone?”

Please, no more innovation! Just let us come to terms with the last lot of changes! We prefer standardisation to innovation! This is the sector where innovators are really gladiators

No motors, gears or levers. 100% virtual physics and yet 100% real acoustics. It doesn’t make sense, but it works breathtakingly well. The catch? It isn’t cheap. Yet.

Where is customer service innovation really happening right now? Is it mostly in sales, brands, marketing, call centers, e-commerce, retailing, CRM, products, social media, mobile, games, finance? These titles show that it’s taking place over the entire spectrum

The offshoring phenomenon has provided strong support for the claim that simply increasing the number of suitable graduates will produce enough ‘potential for innovation’ to restore growth and jobs. Until now.

No British press coverage for a major innovation story: biotech legend Una Ryan secures funding from both the UK’s Department for International Development and the Bill and Melinda Gates foundation

Before the current mainstream recognition of ‘gamification as a business strategy’, these issues were rarely taken seriously by outsiders. Now that we’re all interested, these videos are an utter revelation, even to many insiders

Apart from biology, our physical world is mostly either dumb, rock hard, or both. We use that hard, dumb stuff to make durable things like tools, vehicles and buildings. Biology, although soft, squishy and smart, somehow also manages to grow incredibly hard things, like shells and teeth. Maybe biology can teach us better ways to make hard stuff too

Why is neuroscience suddenly such a hot topic right now? Is it just that the latest brain scan technology allows us to see more detail? The answer is yes, but the implications are far bigger

Jessica Livingstone offers her own feelings about what Y Combinator wants and I try to read between the lines
Renowned educational critic Steve Peha is unconvinced that any of the current or proposed major educational reform initiatives will change anything. Ever.

One irony is that Fred Gage is one of the world’s leading figures in neuroscience, a discipline which was largely spurred by Phineas Gage’s miraculous survival. Another relevant irony (noted in the Wikipedia article about Fred) is that Phineas (1823 – 1860) had no children

There’s a growing interest in introducing an entrepreneurial approach to innovation, whether its happening inside or outside the established organisation

At 12 am one night in 2007, a revolutionary engineering idea popped into Michelle Khine’s head. The rest is history (and chemistry, physics, biotech, nanotech, solar: she seems unstoppable)

Neuroscience offers the prospect of an incontrovertible record of the intentions behind everything we do, so jury trials may eventually be deemed unnecessary. But no chip implanted? Guilty as charged!
Even if you don’t know what on earth a Demand-Side Platform (DSP) is, this panel video offers fascinating insights into the latest things that are keeping people in the online display ad world awake at night
Just trying to describe why over two million viewers think this frivolous-looking video is jaw-dropping will inevitably come out sounding like gobbledygook to all but those who already fully appreciate the sensational breakthrough it represents

We’d all be forgiven for imagining that TechCrunch Disrupt and the DEMO Conference were the only regularly held innovation competition events worth talking about, as far as the tech media were concerned. So imagine my surprise…

“There are venture firms here in The Valley that won’t even fund a company unless they employ lean startup methodologies”

At least five of these forthcoming titles major on a healthcare or safety aspect, illustrating just how far this particular management approach has come from its original niche

Jason ‘Mr. Startups’ Calacanis may not do patents, but he has just done an episode of his weekly TV show where he brought in a seasoned patent attorney and a prolific inventor to take us through the latest developments on the US patent scene

Intrapreneurship is not for the fainthearted. Inside established organisations, officially-sanctioned bastions of executive dragon slaying can sometimes be found, filled with fearless risk-takers discretely licensed to systematically shred the company rulebook in their tireless search for innovation
Computer Bowl 1990, pitting the East Coast against the West Coast (apologies to any other legends present but not listed above)

Nature chuckles at our feeble, stumbling efforts at computation. Its analog computing resources effortlessly deliver dazzling practical intelligence at microscopic scale with zero tolerance for wasted power

The move away from traditional VCs to Angels features strongly in talk about startup investment. So this seemingly contrary view from the very heart of Silicon Valley is intriguing

He asked some industrial designers to come up with something that was “Bob Dylan songs”. His cryptic demands have been described as ‘intentionally unreasonable’. But maybe that’s why they worked

“What do you want to do here?” Get a job. “Sorry, but you’ll need to go straight back home right now, next please. So, what do you want to do here?” Start a business, employ people “Great! please sit over there with the others”

Monsters, zombies, heroes or villains: which of these will we become if video games turn out to be shaping the character of future generations?

A non-fictional man who would only speak using formal logic, a founding genius of computer science. Like Spock, he was much stranger than any ordinary alien. A student of his tells a disturbing story about a different but highly relevant kind of alienation.

Today’s occupiers are in many ways no less ethereal that any lingering spirits which might still be roaming the lonely corridors and passing silently through walls

Nobody invents everything they do, innovating all of the time. Most of the time, we are part of the community, resisting newer untried innovations merely by not abandoning older accepted ones. It’s important for innovators to regularly remind themselves about how it feels to be “everyone else”

For a first-time startup, when the real excitement of early innovation is happening, the daunting business of M&A is usually the last thing on anyone’s mind. But research is showing that the later it starts, the higher the risk

We’ve been looking for a green engineering video ever since our last article on the subject. This excellent briefing definitely makes up for the wait

One theme that appears often in many of these volumes? Discovery processes. If the word ‘innovation’ appears anywhere in your job description, you already know that discovering new discovery processes is a double-edged sword

When things go wrong, you could sometimes be forgiven for imagining that big institutions are indifferent to the effects of social media. This video should clear that up, at least for these household names, which seem fully engaged

New ‘iterative’ startup methodologies, such as Eric Ries’s Lean Startup and Steve Blank’s Customer Development, raise just as many important new questions about investors as they do about startups

What’s it like being interviewed by Paul Graham when you’re applying to Y Combinator? Watch this unmissable video of intense grilling and inspired brainstorming in front of a live audience

TechCrunch writers Paul Carr and Sarah Lacy explore taking this to the next stage: he’s just brought out a memoir, The Upgrade, which breaches confidentiality pledges he made to her. Their unguarded video chat exposes intriguing differences between his blogger and book-writer personas. The book’s film rights have just been sold: so who will play Mike Arrington?

It’s a video of Steve Blank’s first talk after finishing his pioneering Lean LaunchPad course at Stanford

Surprisingly, we had the opposite problem to our usual one with this category: this time we were not quite as inundated with contenders

If you’re thinking: “Aha! at last, a lean startup skeptic! I always suspected all that MVP and pivot stuff was really just snake oil!” then this video is for you. But buckle up, you’re in for a bumpy user experience

Even if you find the average recycling innovation story boringly predictable, this one, as it gathers momentum with one ludicrously lucky sustainability discovery after another, will have you cheering along with the audience

No, it’s not Dave McClure’s customary firehose of expletives that make this video Not Safe For Work. It’s you. You’re Not Safe For Work in a startup, as far as he’s concerned
Science is ‘going virtual’ in a big way: rapidly escalating computing horsepower is turning lots of real-world research into simulation-based experimentation. Is this helping or hindering the latest open science initiatives?
They often seriously hate each other, administration and street folks. But some people out there just don’t care who hates them: they help these seemingly implacable haters help each other, they save lives and they save everyone money
He just said: ‘I hate the term “minimal viable product.” That’s like telling me “we’re shipping without any features because, well, our investors and advisors told us to ship and fix the product later.”
Justin Romack’s demo has to be slowed down quite a bit for us sighted folks watching the video
If Artificial Intelligence is going to automate the world’s entire workforce, we’re all going to need to give up any hope of employment and become startup entrepreneurs and innovation investors instead. They couldn’t possibly automate those, could they?

Startups from Y Combinator, TechStars, Dave McClure’s 500 Startups and Idealab tell us what life feels like, including being rejected by Y Combinator and successfully reapplying!
No dead cows, just real, sustainable beef, made with nothing but yummy stem cells and a touch of magic! All yours for a sizzling €250,000 each. And they’ll get cheaper and cheaper with every passing year (can we call that Moo’s law?)
Would you invest in founders pitching a project that you didn’t really believe in, for reasons you didn’t tell them about?
The practical essence of your personality will soon be surprisingly easy to steal. The coming generation of virtual reality will be able to appropriate so much of what it is to be you, that things could get seriously out of control
An onstage tournament in which in-house advocates from either side make their case in front of a live audience and we all try to read between the lines
They have another mission-critical job that you probably didn’t know about. They are required to make air travel on this planet safer, more efficient and more environmentally friendly for everyone
‘Nobody should claim to be doing innovation’ already sounds like a pretty shocking proposition, but it soon becomes clear that conventional ideas are the last thing to expect from the conversation captured in this extraordinary video
We’re going beyond innovation here. Instead of the latest technology, we’re getting a tantalising glimpse of things that don’t yet exist, but are making exciting progress in the lab and could ultimately represent enormous advances in almost every field of science and technology if they fulfil their promise
The Economist calls you a post-materialist: you don’t feel driven by materialist ambitions. You just need enough to maintain your existing lifestyle, rather than improve it. But what does ‘not being your own boss’ mean in this context?
Somehow, something as seemingly mundane as an ‘online errand service’ is helping us discover surprising new ways to support each other
How do you draw the line between entertainment and non-entertainment uses? Who drives the innovation? Does industry get its inspiration from cinema and gaming, or is the entertainment business merely exploiting the technological advances made by the manufacturing industry?
An opportunity to watch Steve Chu, US Energy Secretary, running us through a list of technologies which he hopes will help America reassert itself in the rapidly intensifying struggle for competitiveness and maybe even its very survival
They’ve been around longer. $138m revenue, 55 startups and you’ve never even heard of them
Fred Wilson (the VC world’s leading blogger) makes an insightful comparison between first time and serial entrepreneurs. I was thinking through the ‘who do you go to?’ question
For some unfathomable reason, we’ve never covered anything on games design luminary Will Wright, and if that wasn’t bad enough, we never even knew that his latest major project wasn’t even a game.
Tractors, farm equipment, built at around one eighth the cost. Industrial equipment too. Superior design. Handmade quality. Problem? Investment. Solve it, and Jakubowski becomes a household word. That might just happen anyway.

Apart from being about new ideas and leadership (which is, after all, the entire reason for the list) there’s not much in common between these volumes, other than each one focussing on some unique but pertinent aspect
This lab is turning the way social science research is conducted on its head, and that’s not just because the whole thing is online
Surprisingly, these influential and outspoken panellists, who you might expect would have opposing views on just about everything, seem to be having a candid, but surprisingly civil conversation about a very controversial subject: was it something in the water?

Going beyond ticking boxes, complying with regulations or keeping up with the latest initiatives, ecological development guru Bill Reed uproots just about everything we think we know about ‘green’ and asks whether we are really delving deeply enough

This starts off as a talk about startup methodology but somehow manages to morph into a sales pitch for an intriguing new solar technology. If you’re able to keep up with Bill Gross’s sometimes ferocious pace of delivery, stick with it, it’s well worth the ride
Remember the software that could use lots of casually taken photos of a scene and somehow combine them into a 3D model that you could then navigate in a breathtakingly intuitive way? Well, what if you could do the same with independently created scientific research databases?
It’s a funny old world where it takes Wired Magazine to show the medical fraternity how truly unintelligible (but life-critical) gibberish can be transformed in ways that allow us to take control of our own well being
I just read this question on Quora: ‘What good books tell the story of the business model iterations and pivots of a notable company?’ My response is not a book, but a video of a talk at Y Combinator Startup School
These titles aren’t available yet, but you may need to move quickly once they are. Agile software development may be rapidly moving into the mainstream, but that doesn’t mean the innovation in that field is slowing down
Disappointingly, behaviour change through ‘just gamifying your own health tracking’ doesn’t always work very well. Why not? It just might turn out that, for most of us, personal health tracking is not really a single player game.

This is about using what The Economist calls artificial artificial intelligence (like Mechanical Turk, which uses people as artificial computers) to enhance (artificially intelligent) machine vision
No, you don’t need to be a brain surgeon to find this fascinating: bio-integrated electronics is full of unimaginably weird but useful things you can do with things like, you know, live brains. It’s all about making electronic things rubbery
A new report by the US Bureau of Labor Statistics is being mistakenly interpreted as showing that startups are creating fewer jobs. This view somehow manages to completely ignore those odd things investors call ‘exits’.
Investors treat ‘startup founders entrepreneurial inexperience’ as an occupational hazard. Accelerators ‘parachute-in’ entrepreneurial experience in the form of ‘startup acceleration mentors’. Isn’t it time to ask some big questions about this?
After my initial TED-talk-inspired enthusiasm, I became seriously disheartened by the seemingly unanswerable criticisms of Khan Academy’s fairly unadventurous ‘talk and chalk’ style tutorial videos as not really representing a genuine step forward in education. But…
Sharing is useful, right? Motherhood and apple pie, surely? The stampede of sacred cows being ruthlessly sacrificed in this extraordinary video bonfire of academic vanities lends it an intoxicating but perhaps far too beefy aroma for some
The investors need to be wealthy ($1m+) and few (maximum 500) and the business too small to IPO. Facebook tore that last rule apart. What if the other rules are also eventually relaxed?
Carmack systematically trashes proceduralism
Biotechnology book publishing is soaring. It’s making the job of keeping track of ‘what are the most interesting titles coming out, and when?’ almost impossible. This is our first attempt

Biology has replaced chemistry as the primary science behind drug discovery: how did this transformation begin, who was involved, and how did it get funded?
Investment legend Roger McNamee says mobile has already killed search. Smartphone users hardly use search. Is Google no longer the gatekeeper to the web, business, the world? Will Google+ put them back in the money? Does today’s ‘Facebook for business’ launch roll the dice once again?
Should employers turn their business into startup factories? How could we make this happen?
They look like apps but they’re really stealth development tools which give your customers the ability to build themselves their own app for your service
You’ve been top of the TechMeme leaderboard for quite a while. Here comes Business Insider
I had to work my way through an enormous number of clips to put this together, but I still only scratched the surface. I had to do it now, because soon, there are going to be just too many to even attempt this with any sense of purpose.
If you loved that awesome video of advertising icon Alex Bogusky and his dad, reserve yourself some time to watch two generations of Stanford stars tell how their vocations unexpectedly converged
Startups attempt innovation under conditions of extreme uncertainty. Is it possible that we can find new ways to solve the world’s biggest problems using ‘extreme uncertainty’?

This astonishing video takes environmental innovation to its outer limits: you’ll need to be pretty imaginative to find a way to invest in the ideas it explores
Everyone’s telling us that this young woman has used videos in a new, inspiring way, so we went on a hunt for the videos they inspired
It may be a cash cow, but a ‘Windows first’ policy is holding back Windows Phone in a field dominated by Android
Does this talk, four months before the announcement offer the best insight into the thinking behind it?
Robert’s insight into Adobe’s next OS was probably right, perhaps he just didn’t take it far enough
You’ll probably scrutinise ‘angel disruptus maximus’ Naval Ravikant’s latest video much more thoroughly than I have, just to see how his predictions have changed since the last talk of his that we covered

Can we build robots that can be taught in the same way that humans teach each other? That’s not how we teach robots now. Is this the way to make robots more useful in natural disasters?

What are the differences in social media activity when comparing employed and unemployed people? Would you take on a job that was underpaid and unattractive, start or join a fun but non-paying, penniless startup, anything so as not to have fewer social experiences to share online?
‘My twelve year old son has autism, and has a terrible time with math. We have tried everything, viewed everything, bought everything. We stumbled upon your video on decimals, and it got through! Then we went on to the dreaded fractions. Again, he got it! We could not believe it! He is so excited.’
Video curation, the final frontier. These are the voyages of the iij Enterprise. Her ongoing mission: to explore strange new innovation videos, to disregard things that have caused them to be ignored or dismissed and to put them into context
You’ll need to watch this video if your knowledge of the issues has so far been mostly constrained to news coverage
It looks like the enviable track record of startup accelerators like TechStars and Y Combinator derives from identifying something you might call ‘Foundational Capability’ as the basis for startup success, but there is a dark side
What is the range of subject matter in our ‘spring collection’ of (weighty and in some cases expensive) Social Media volumes? Integration, culture, storytelling, journalism, transmedia, immersion, law, enterprise, strategy, teaching, meaning, creativity, identity, invention and belonging